Parvo Virus Infection in Dogs
What is Parvo Virus?
Parvo is a contagious disease of dogs. It is believed that this virus originated from Feline Pan Leukopenia virus. Parvo is a non-enveloped single stranded DNA virus which can persist in indoor/room condition for at least two months and even for years in outdoor conditions.
Dogs Susceptibility:
Young dogs of 6 weeks to 6 months of age who are unvaccinated or incompletely vaccinated are most susceptible. Rottweilers, Doberman Pinschers, American Pit Bull Terriers, English Springer Spaniels, and German Shepherds are especially more susceptible to this virus.
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Pathogenesis (How diseases develops in dog)?
Parvo enters a dog body through oral or nasal route when coming in contact with virus containing feces or other things like fomites etc. After entry, virus replicates in the lymphoid tissue of oropharynx. Then this virus spreads in the whole body through blood circulation. This virus preferably destroys rapidly dividing cells of small intestine crypt epithelium, lymphopoietic tissue and bone marrow. As a result of destruction of intestinal epithelium, its necrosis, atrophy, low absorption capacity occurs and there are chances that bacteria may travel from gut to blood, causing bacteremia.
Signs and Symptoms:
Within 5 to 6 days of infection, enteritis develops. Initial clinical signs may be non-specific e.g.
- Lethargy
- Anorexia
- Fever
- Vomiting
- Bloody diarrhea
- Diarrhea
- Dehydration
- Depression
- Low heart beat
- Low body temperature (Hypothermia)
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